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Moreover, it is unlikely santoro a single mechanism accounts for the numerous reported experimental findings that appear to represent examples krysta oncogene dependency, and therefore, this still represents an important area for further investigation. Considering the potentially important therapeutic opportunity presented by oncogene addiction, there will undoubtedly be further mechanistic insights on the horizon. View all Oncogene addiction: setting the stage for molecularly targeted cancer therapy Sreenath V.

Previous Section Next Section. View this table: In this window In a new window. Table 1. Examples of dominant oncogenes that confer oncogene addiction. Table 2. Examples of tumor suppressor genes that confer oncogene model.

Figure 1. Figure 2. Previous Section. Adachi, J. Cell Growth Differ. Akeno-Stuart, N. Naughtyamera Res. Alarcon, R. Arber, N. Apoptosis 4 : — Arbiser, J. Arvanitis, C. Cancer Biol. Balaban, N. Science : — Beer, S. PLoS Biol. CrossRef Medline Nude Scholar.

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Cell Death Differ.

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Davies, H. Dean, M. Cancer 5 : — Decaudin, D. Cancer : — Deininger, M. Dhar, N. Dong, G. Drosten, M. Surgery : — Gene Ther. Druker, B. Emanuel, S. Engelman, J. Esquela-Kerscher, A. Cancer 6 : — Evan, G. Cell 69 : — B Biol. Fabbri, M. Fanton, C. Felsher, D. Cell 4 : — Ferbeyre, G. Fisher, G. Fleming, T. Folkman, J. Princess Takamatsu Symp. Frisch, S.

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Cell Biol. Galkin, A. Gallagher, A. Garton, A. Golas, J. Goldman, C.

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Gomez-Manzano, C. Grand, E. Leukemia 18 : — Green, D. Krysta Cell 1 : 19 — Groth, A. Guerin, M. Oncogene Res. Halatsch, M. Hanahan, D. Cell : 57 — Harrington, E. EMBO J. Hata, T. Heinrich, M. Hiebert, S. Hietanen, S. Hingorani, S. Hirota, Santoro. Hsu, F. Cancer Invest. Hua, J. Hudis, C. Hudziak, R. Hueber, A. Trends Genet. Iliopoulos, D. Irwin, M. Jain, M. Ji, Nude. Cancer Cell 9 : — Johnson, D. Kaelin, W. Kamb, A. Cell 14 : nude Karasarides, M. Oncogene 23 : — Kauffmann-Zeh, A.

Kerbel, R. Kilic, T. Kim, K. Kim, P. Kinzler, K. Cell model : — Kohl, N. Kondo, S. Kondo, T. Kowalik, T. Krystal, G. Kurata, T. Laird, A. Lewis, K. Li, F. Liao, D. Cancer Metastasis Rev. Libermann, T. Liu, M. Krysta, Y. Loke, S.

Loughran, O. Lowe, S. Luwor, R. Lynch, T. Ma, P. MacLaren, A. Oncogene 19 : — Maity, A. Manfredi, M. Martins, C. Marumoto, T.

Cancer 5 : 42 — Matsubara, H. Oncogene 26 : — Mayo, M. McCormick, F. Cancer santoro : — Mills, G. Miranda, E. Mologni, L. Moriyama, T. Morris, S. Mukhopadhyay, T. Mulloy, R. Nishikawa, R. Nister, M. Norton, J. Ohnishi, Y. Cancer 71 : — Paez, J. Pao, W. PLoS Med 2 : e73doi: Parthasarathy, R. Paterson, J. Model, A. Petrangolini, G.

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Oncogene addiction: setting the stage for molecularly targeted cancer therapy

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